Alzheimer’s disease

Salk Institute maps 1,000 hidden brain microproteins linked to Alzheimer’s

Scientists at the Salk Institute have assembled the first atlas of microproteins in the human frontal cortex, cataloging over 1,000 previously uncharacterized tiny proteins and uncovering a potential link between one of them and immune cell dysfunction in Alzheimer's disease.…

Study finds key Alzheimer’s brain damage pathway starts in lymph nodes

A key driver of Alzheimer's-like brain damage originates not in the brain itself but in the body's lymph nodes, according to a study published Thursday in Nature Neuroscience. Researchers at Washington University School of Medicine in St. Louis found in…

Nanoparticles reverse Alzheimer’s decline in mice, study finds

Researchers at the University of South Carolina have developed a nanoparticle-based therapy that reversed cognitive decline in mice with Alzheimer's disease by converting brain support cells into functioning neurons — a approach that avoids permanent genetic modifications and could chart…

FDA clears Roche, Eli Lilly blood test for Alzheimer’s

The U.S. Food and Drug Administration has cleared a blood test developed by Roche in collaboration with Eli Lilly that can help detect signs of Alzheimer's disease through a simple blood draw, potentially transforming how the condition is diagnosed across…

Study finds Alzheimer’s brain changes 7 years before plaques appear

Alzheimer's disease may leave detectable traces in the brain more than seven years before amyloid plaques — long considered the earliest measurable sign of the condition — become visible on PET scans, according to a study published this week in…

First complete marmoset genome maps 76 Alzheimer’s-linked genes

Researchers at the University of California, Santa Cruz Genomics Institute have published the first gapless, telomere-to-telomere genome of the common marmoset, a milestone they say will sharpen the study of Alzheimer's disease and other neurodegenerative conditions. The findings, published Thursday…

Blood test predicts Alzheimer’s risk up to a decade early

A single blood test measuring levels of the biomarker p-tau217 can reliably predict which cognitively healthy older adults will develop Alzheimer's-related cognitive impairment years before symptoms appear, according to a large-scale study published July 14 in JAMA and presented at…

Roche unveils trial to prevent Alzheimer’s before symptoms appear

Roche has revealed the design of PrevenTRON, a Phase III trial that will test whether its experimental drug trontinemab can prevent Alzheimer's disease in people who show no cognitive symptoms but carry biological markers of the illness. The study design…

Blood test helps primary care doctors diagnose Alzheimer’s with 90% accuracy, study finds

A blood test measuring Alzheimer's disease biomarkers enabled primary care physicians to diagnose the condition with roughly 90% accuracy — nearly matching specialists — according to new real-world data presented at the Alzheimer's Association International Conference (AAIC) 2026 in London…

Human-safe drug repairs DNA damage in Alzheimer’s mouse model

Neuroscientists at King's College London have found that a drug already shown to be safe in humans can reduce multiple features of Alzheimer's disease in mice by repairing broken DNA in neurons and reducing brain inflammation, according to a study…

New cell death mechanism found in Alzheimer’s brains

Researchers at King's College London have identified a previously unknown form of programmed cell death called karyoptosis in the brains of patients with Alzheimer's disease and frontotemporal dementia, a discovery that could reshape understanding of how neurons are lost in…